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REAL WORLD EVENT DISCUSSIONS
new deadly human-to-human-transmissible coronavirus emerges out of China
Monday, May 18, 2020 6:42 PM
1KIKI
Goodbye, kind world (George Monbiot) - In common with all those generations which have contemplated catastrophe, we appear to be incapable of understanding what confronts us.
Monday, May 18, 2020 7:18 PM
SIGNYM
I believe in solving problems, not sharing them.
Monday, May 18, 2020 7:42 PM
Monday, May 18, 2020 9:10 PM
Quote:If it’s working in Georgia, why can’t it work here? Georgia’s flattening curve defied all scientific logic. Pandemics don’t end because the economy is suffering and we want them to. And yet data don’t lie. Or do they? Thanks to the Atlanta Journal Constitution, we now know things did indeed look too good to be true. Georgia’s coronavirus numbers looked so rosy because officials misrepresented the data in such a way it’s difficult to believe it wasn’t done on purpose. The state of Georgia made it look like its covid cases were going down ***by putting the dates out of order on its chart*** May 5 was followed by April 25, then back to May again, whatever made it look like a downslope. https://t.co/H8pSvY6rxn — David Fahrenthold (@Fahrenthold) May 17, 2020 “I have a hard time understanding how this happens without it being deliberate,” microbiology and molecular genetics PhD and state Rep. Jasmine Clark told the Journal Constitution. “Literally nowhere ever in any type of statistics would that be acceptable.” Georgia isn’t the only state itching to reopen that has a penchant for dubious data. Florida actively tried suppressing county coroners from releasing COVID-19 death tallies.
Monday, May 18, 2020 9:48 PM
Tuesday, May 19, 2020 5:20 PM
Tuesday, May 19, 2020 6:46 PM
Thursday, May 21, 2020 4:08 AM
JAYNEZTOWN
Quote:Originally posted by 1KIKI: COVID-19 health risk due to pre-existing conditions grey is lowest, dark brown is highest
Quote:Originally posted by 6IXSTRINGJACK: They're not going to ever be any worse off than NYC was, and at the end of the day it really wasn't that bad there despite all he pissing and moaning.
Thursday, May 21, 2020 5:22 AM
6IXSTRINGJACK
Thursday, May 21, 2020 5:43 PM
Quote:As of 12midnight 7/13 cases 1~~,~~~ deaths 3,~~~
Quote:As of 12midnight 7/12 cases 1~~,~~~ deaths 3,~~~
Quote:As of 12midnight 7/11 cases 130,242 deaths 3,793
Quote:As of 12midnight 7/10 cases 127,358 deaths 3,738
Quote:As of 12midnight 7/9 cases 124,738 deaths 3,689
Quote:As of 12midnight 7/8 cases 123,004 deaths 3,642
Quote:As of 12midnight 7/7 cases 120,539 deaths 3,579
Quote:As of 12midnight 7/6 cases 116,570 deaths 3,534
Quote:As of 8pm 7/5 systems update cases ~~~~~ deaths ~~~~~
Quote:As of 8pm 7/4 systems update cases ~~~~~ deaths ~~~~~
Quote:As of 8pm 7/3 systems update cases ~~~~~ deaths ~~~~~
Quote:As of 8pm 7/2 systems update cases ~~~~~ deaths ~~~~~ Revised Health Officer Order Requires Closure of Indoor On- Site Dining and Other Indoor Activities
Quote:As of 8pm 7/1 cases 107,667(excludes some areas) deaths 3,454
Quote:As of 8pm 6/30 cases 105,507 deaths 3,402 Beaches Closed, Fireworks Displays Prohibited During 4th of July Weekend to Prevent Spread of COVID-19
Quote:As of 8pm 6/29 cases 100,772 deaths 3,326 Los Angeles County Bars Closing
Quote:As of 8pm 6/28 cases 103,529 deaths 3,369
Quote:As of 8pm 6/27 cases 97,894 deaths 3,305
Quote:As of 8pm 6/26 cases 95,371 deaths 3,285
Quote:As of 8pm 6/25 cases 93,232 deaths 3,267
Quote:As of 8pm 6/24 cases 91,467 deaths 3,246
Quote:As of 8pm 6/23 cases 89,490 deaths 3,205
Quote:As of 8pm 6/22 cases 88,262 deaths 3,171
Quote:As of 8pm 6/21 cases 85,942 deaths 3,137
Quote:As of 8pm 6/20 cases 83,397 deaths 3,120
Quote:As of 8pm 6/19 cases 81,636 deaths 3,110
Quote: As of 8pm 6/18 cases 79,609 deaths 3,063
Quote:As of 8pm 6/17 cases 78,227 deaths 3,027
Quote:As of 8pm 6/16 cases 77,189 deaths 2,991
Quote:As of 8pm 6/15 cases 75,084 deaths 2,959
Quote:As of 8pm 6/14 cases 73,791 deaths 2,926
Quote:As of 8pm 6/13 cases 73,018 deaths 2,907
Quote:As of 8pm 6/12 cases 72,023 deaths 2,890
Quote:As of 8pm 6/11 cases 70,476 deaths 2,832
Quote:As of 8pm 6/10 cases 68,875 deaths 2,813
Quote:As of 8pm 6/9 cases 67,064 deaths 2,768
Quote:As of 8pm 6/8 cases 65,822 deaths 2,707
Quote:As of 8pm 6/7 cases 64,644 deaths 2,655
Quote:As of 2pm* 6/6 cases 63,844 deaths 2,645
Quote:As of 8pm 6/5 cases 62,338 deaths 2,620
Quote:As of 8pm 6/4 cases 61,045 deaths 2,565
Quote:As of 8pm 6/3 cases 59,650 deaths 2,531
Quote:As of 8pm 6/2 cases 58,234 deaths 2,489
Quote:As of 8pm 6/1 cases 57,118 deaths 2,443
Quote:As of 8pm 5/31 cases 55,968 deaths 2,384
Quote:As of 8pm 5/30 cases 54,996 deaths 2,362
Quote:As of 8pm 5/29 cases 53,651 deaths 2,338
Quote:As of 8pm 5/28 cases 51,562 deaths 2,290
Quote:As of 8pm 5/27 cases 49,774 deaths 2,241
Quote:As of 8pm 5/26 cases 48,700 deaths 2,195
Quote:As of 8pm 5/25 cases 47,822 deaths 2,143
Quote:As of 8pm 5/24 cases 46,018 deaths 2,116
Quote:As of 8pm 5/23 cases 44,988 deaths 2,104
Quote:As of 8pm 5/22 cases 44,055 deaths 2,090
Quote:As of 8pm 5/21 cases 43,052 deaths 1,072
Quote:As of 8pm 5/20 cases 42,037 deaths 2,016
Thursday, May 21, 2020 5:45 PM
Thursday, May 21, 2020 5:48 PM
Thursday, May 21, 2020 6:05 PM
Thursday, May 21, 2020 6:07 PM
Thursday, May 21, 2020 6:13 PM
Thursday, May 21, 2020 7:43 PM
SECOND
The Joss Whedon script for Serenity, where Wash lives, is Serenity-190pages.pdf at https://www.mediafire.com/two
Friday, May 22, 2020 3:41 AM
Quote:Originally posted by SIGNYM: So I took another look at divoc-91 deaths/wk/MM and I tried to put states into one of four categories: These started low and mostly stayed low, and are now at or near zero: Alaska, Arkansas, Hawaii, Idaho, Kansas (maybe, but has a tick up at the end),
Quote: Maine, Montana, Oklahoma, Oregon, Utah, Vermont, Tennesee, Texas (maybe, same issue),
Quote: West Virginia, and Wyoming. Took an initial jump up but have since plateaued. The jump up indicates that they have some risk factors for transmission, the plateau shows that they've reached some kind of equilibrium with the virus: California, Maryland, Pennsylvania, Mississippi
Quote: Nebraska
Quote: Nevada, Florida, Ohio,
Quote:, Georgia, Indiana, Kentucky,
Quote:Louisiana, Michigan, Massachusetts, South Carolina, and (of course) the big three: New York, Connecticut, and New Jersey, And the surprises. These states hae done nothing but go up and are STILL going up: Illinois
Quote: New Hampshire
Quote: Iowa (Iowa???)
Quote:Virginia
Quote:Alabama,
Quote: and New Mexico.
Friday, May 22, 2020 10:53 AM
Friday, May 22, 2020 12:00 PM
Quote:Originally posted by 6IXSTRINGJACK: At the end of the day, this will all be a huge nothing burger and I will be right about it, just like I almost always am. Do Right, Be Right. :)
Friday, May 22, 2020 1:38 PM
Friday, May 22, 2020 3:48 PM
Friday, May 22, 2020 5:30 PM
Friday, May 22, 2020 11:53 PM
Friday, May 22, 2020 11:57 PM
Saturday, May 23, 2020 12:07 AM
Saturday, May 23, 2020 12:18 AM
Saturday, May 23, 2020 12:36 AM
Saturday, May 23, 2020 12:41 AM
Saturday, May 23, 2020 12:46 AM
Quote:Originally posted by SIGNYM: Please ignore SIX on this topic. He's making it all about himself and not bringing any information to the table. ----------- Pity would be no more, If we did not MAKE men poor - William Blake #WEARAMASK
Saturday, May 23, 2020 4:45 AM
Saturday, May 23, 2020 5:08 AM
Saturday, May 23, 2020 10:38 AM
Saturday, May 23, 2020 10:42 AM
Saturday, May 23, 2020 10:46 AM
Saturday, May 23, 2020 6:24 PM
Quote:Originally posted by 6IXSTRINGJACK: In denial of what? I'm still waiting for anything close to a serious death toll. It does not exist. In the meantime, death rates are extremely inaccurate and overblown since any legit testing has not been implemented, and we still haven't even begun to test for people who have antibodies and were never tested in the first place. Big. Fucking. Nothingburger. Do Right, Be Right. :)
Saturday, May 23, 2020 7:23 PM
Sunday, May 24, 2020 6:27 AM
Sunday, May 24, 2020 10:57 AM
Quote:Originally posted by SIGNYM: Quote:Originally posted by 6IXSTRINGJACK: In denial of what? I'm still waiting for anything close to a serious death toll. It does not exist. In the meantime, death rates are extremely inaccurate and overblown since any legit testing has not been implemented, and we still haven't even begun to test for people who have antibodies and were never tested in the first place. Big. Fucking. Nothingburger. Do Right, Be Right. :) THIS is why we're laughing at you. The "serious death toll" has already occurred. Maybe not in YOUR little corner of the world, but it's happened and is still happening. ----------- Pity would be no more, If we did not MAKE men poor - William Blake #WEARAMASK
Sunday, May 24, 2020 10:58 AM
Sunday, May 24, 2020 12:43 PM
Sunday, May 24, 2020 12:57 PM
Sunday, May 24, 2020 1:25 PM
Sunday, May 24, 2020 2:39 PM
Sunday, May 24, 2020 5:22 PM
Monday, May 25, 2020 4:33 AM
Monday, May 25, 2020 5:24 AM
Monday, May 25, 2020 9:14 AM
Quote:Originally posted by 1KIKI: ‘It’s something I have never seen’: How the Covid-19 virus hijacks cells A deep dive into how the new coronavirus infects cells has found that it orchestrates a hostile takeover of their genes unlike any other known viruses do, producing what one leading scientist calls “unique” and “aberrant” changes. Recent studies show that in seizing control of genes in the human cells it invades, the virus changes how segments of DNA are read, doing so in a way that might explain why the elderly are more likely to die of Covid-19 and why antiviral drugs might not only save sick patients’ lives but also prevent severe disease if taken before infection. The first group of genes produces interferons. These proteins, which infected cells release, are biological semaphores, signaling to neighboring cells to activate some 500 of their own genes that will slow down the virus’ ability to make millions of copies of itself if it invades them. This lasts seven to 10 days, tenOever said, controlling virus replication and thereby buying time for the second group of genes to act. This second set of genes produce their own secreted proteins, called chemokines, that emit a biochemical “come here!” alarm. When far-flung antibody-making B cells and virus-killing T cells sense the alarm, they race to its source. If all goes well, the first set of genes holds the virus at bay long enough for the lethal professional killers to arrive and start eradicating viruses. “Most other viruses interfere with some aspect of both the call to arms and the call for reinforcements,” tenOever said. “If they didn’t, no one would ever get a viral illness”: The one-two punch would pummel any incipient infection into submission. SARS-CoV-2, however, uniquely blocks one cellular defense but activates the other, he and his colleagues reported in a study published last week in Cell. They studied healthy human lung cells growing in lab dishes, ferrets (which the virus infects easily), and lung cells from Covid-19 patients. In all three, they found that within three days of infection, the virus induces cells’ call-for-reinforcement genes to produce cytokines. But it blocks their call-to-arms genes — the interferons that dampen the virus’ replication. The result is essentially no brakes on the virus’s replication, but a storm of inflammatory molecules in the lungs, which is what tenOever calls an “unique” and “aberrant” consequence of how SARS-CoV-2 manipulates the genome of its target. In another new study, scientists in Japan last week identified how SARS-CoV-2 accomplishes that genetic manipulation. Its ORF3b gene produces a protein called a transcription factor that has “strong anti-interferon activity,” Kei Sato of the University of Tokyo and colleagues found — stronger than the original SARS virus or influenza viruses. The protein basically blocks the cell from recognizing that a virus is present, in a way that prevents interferon genes from being expressed. In fact, the Icahn School team found no interferons in the lung cells of Covid-19 patients. Without interferons, tenOever said, “there is nothing to stop the virus from replicating and festering in the lungs forever.” That causes lung cells to emit even more “call-for-reinforcement” genes, summoning more and more immune cells. Now the lungs have macrophages and neutrophils and other immune cells “everywhere,” tenOever said, causing such runaway inflammation “that you start having inflammation that induces more inflammation.” At the same time, unchecked viral replication kills lung cells involved in oxygen exchange. “And suddenly you’re in the hospital in severe respiratory distress,” he said. In elderly people, as well as those with diabetes, heart disease, and other underlying conditions, the call-to-arms part of the immune system is weaker than in younger, healthier people, even before the coronavirus arrives. That reduces even further the cells’ ability to knock down virus replication with interferons, and imbalances the immune system toward the dangerous inflammatory response. The discovery that SARS-CoV-2 strongly suppresses infected cells’ production of interferons has raised an intriguing possibility: that taking interferons might prevent severe Covid-19 or even prevent it in the first place, said Vineet Menachery of the University of Texas Medical Branch. In a study of human cells growing in lab dishes, described in a preprint (not peer-reviewed or published in a journal yet), he and his colleagues also found that SARS-CoV-2 “prevents the vast amount” of interferon genes from turning on. But when cells growing in lab dishes received the interferon IFN-1 before exposure to the coronavirus, “the virus has a difficult time replicating.” After a few days, the amount of virus in infected but interferon-treated cells was 1,000- to 10,000-fold lower than in infected cells not pre-treated with interferon. (The original SARS virus, in contrast, is insensitive to interferon.) Ending the pandemic and preventing its return is assumed to require an effective vaccine to prevent infection and antiviral drugs such as remdesivir to treat the very sick, but the genetic studies suggest a third strategy: preventive drugs. It’s possible that treatment with so-called type-1 interferon “could stop the virus before it could get established,” Menachery said. Giving drugs to healthy people is always a dicey proposition, since all drugs have side effects — something considered less acceptable than when a drug is used to treat an illness. “Interferon treatment is rife with complications,” Menachery warned. The various interferons, which are prescribed for hepatitis, cancers, and many other diseases, can cause flu-like symptoms. But the risk-benefit equation might shift, both for individuals and for society, if interferons or antivirals or other medications are shown to reduce the risk of developing serious Covid-19 or even make any infection nearly asymptomatic. Interferon “would be warning the cells the virus is coming,” Menachery said, so such pretreatment might “allow treated cells to fend off the virus better and limit its spread.” Determining that will of course require clinical trials, which are underway. “It’s something I have never seen in my 20 years of” studying viruses, said virologist Benjamin tenOever of the Icahn School of Medicine at Mount Sinai, referring to how SARS-CoV-2, the virus that causes Covid-19, hijacks cells’ genomes. The “something” he and his colleagues saw is how SARS-CoV-2 blocks one virus-fighting set of genes but allows another set to launch, a pattern never seen with other viruses. Influenza and the original SARS virus (in the early 2000s), for instance, interfere with both arms of the body’s immune response — what tenOever dubs “call to arms” genes and “call for reinforcement” genes. https://www.statnews.com/2020/05/21/coronavirus-hijacks-cells-in-unique-ways/
Monday, May 25, 2020 1:50 PM
Monday, May 25, 2020 2:01 PM
Monday, May 25, 2020 5:19 PM
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