REAL WORLD EVENT DISCUSSIONS

Score another one for PN

POSTED BY: FREMDFIRMA
UPDATED: Tuesday, January 29, 2013 11:59
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Monday, January 28, 2013 10:14 AM

FREMDFIRMA



He might be crazy, but yanno, sometimes he does have a point.
http://tvtropes.org/pmwiki/pmwiki.php/Main/TheCuckoolanderWasRight

Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491930/
Quote:

Background: Although fluoride may cause neurotoxicity in animal models and acute fluoride poisoning causes neurotoxicity in adults, very little is known of its effects on children’s neurodevelopment.

Objective: We performed a systematic review and meta-analysis of published studies to investigate the effects of increased fluoride exposure and delayed neurobehavioral development.

Methods: We searched the MEDLINE, EMBASE, Water Resources Abstracts, and TOXNET databases through 2011 for eligible studies. We also searched the China National Knowledge Infrastructure (CNKI) database, because many studies on fluoride neurotoxicity have been published in Chinese journals only. In total, we identified 27 eligible epidemiological studies with high and reference exposures, end points of IQ scores, or related cognitive function measures with means and variances for the two exposure groups. Using random-effects models, we estimated the standardized mean difference between exposed and reference groups across all studies. We conducted sensitivity analyses restricted to studies using the same outcome assessment and having drinking-water fluoride as the only exposure. We performed the Cochran test for heterogeneity between studies, Begg’s funnel plot, and Egger test to assess publication bias, and conducted meta-regressions to explore sources of variation in mean differences among the studies.

Results: The standardized weighted mean difference in IQ score between exposed and reference populations was –0.45 (95% confidence interval: –0.56, –0.35) using a random-effects model. Thus, children in high-fluoride areas had significantly lower IQ scores than those who lived in low-fluoride areas. Subgroup and sensitivity analyses also indicated inverse associations, although the substantial heterogeneity did not appear to decrease.

Conclusions: The results support the possibility of an adverse effect of high fluoride exposure on children’s neurodevelopment. Future research should include detailed individual-level information on prenatal exposure, neurobehavioral performance, and covariates for adjustment.


-Frem

yes, I read scientific journals, now shut up.

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Monday, January 28, 2013 10:24 AM

BYTEMITE


Quote:

because many studies on fluoride neurotoxicity have been published in Chinese journals only.


I've read some of them as well, published around the turn of the millenium. I'm not sure this is "the cloudcuckoolander was right" so much as "this is kind of obvious guys."

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Monday, January 28, 2013 10:36 AM

JONGSSTRAW


"You know when fluoridation first began? Nineteen hundred and forty-six. 1946, Mandrake. How does that coincide with your post-war Commie conspiracy, huh? It's incredibly obvious, isn't it? A foreign substance is introduced into our precious bodily fluids without the knowledge of the individual. Certainly without any choice. That's the way your hard-core Commie works. Do you realize that in addition to fluoridating water, why, there are studies underway to fluoridate salt, flour, fruit juices, soup, sugar, milk... ice cream. Ice cream, Mandrake, children's ice cream." ... General Jack Ripper


Definitely worth starting a toe-to-toe nookular war over!





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Tuesday, January 29, 2013 11:59 AM

M52NICKERSON

DALEK!


It should be noted that the children the study looked at are often exposed to floride levels much higher than are allowed in drinking water in the US.

I do not fear God, I fear the ignorance of man.

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